The study titled “Association of Endothelial Dysfunction With Chronic Marijuana Smoking and THC-Edible Use,” published in JAMA Cardiology in May 2025, investigates the impact of chronic cannabis use on vascular endothelial function. The research reveals that both chronic marijuana smoking and ingestion of THC-containing edibles are associated with impaired endothelial function, akin to the dysfunction observed in tobacco smokers, albeit potentially through different mechanisms. JAMA Network+3JAMA Network+3JAMA Network+3JAMA Network

Study Overview

• Design: Cross-sectional study

• Participants: 55 individuals

• Objective: To determine whether chronic cannabis use correlates with vascular endothelial dysfunctionJAMA Network+2JAMA Network+2JAMA Network+2arXiv+2JAMA Network+2JAMA Network+2JAMA Network+1JAMA Network+1

   

   

Key Findings

• Chronic cannabis users exhibited impaired vascular endothelial function.

• The degree of dysfunction was comparable to that seen in chronic tobacco smokers.

• The underlying mechanisms of endothelial impairment may differ between cannabis and tobacco users.arXiv+3JAMA Network+3JAMA Network+3JAMA Network+1JAMA Network+1

   

   

Clinical Implications

These findings suggest that chronic cannabis use, whether through smoking or ingestion of THC edibles, may have deleterious effects on vascular health. Given the similarities in endothelial dysfunction between cannabis and tobacco users, healthcare providers should consider counseling patients on the potential cardiovascular risks associated with long-term cannabis consumption.

Limitations

• Sample Size: The study’s relatively small cohort (55 participants) may limit the generalizability of the findings.

• Study Design: As a cross-sectional study, it can identify associations but cannot establish causality.

• Confounding Factors: Potential confounders, such as concurrent use of other substances or underlying health conditions, may influence the results.JAMA Network

   

   

Conclusion

The study provides evidence that chronic cannabis use is associated with endothelial dysfunction, a precursor to various cardiovascular diseases. While the mechanisms may differ from those of tobacco-induced dysfunction, the similar outcomes underscore the need for awareness regarding the cardiovascular implications of long-term cannabis use.Further longitudinal studies with larger populations are warranted to explore these associations in more depth and to elucidate the underlying biological mechanisms.JAMA Network+3JAMA Network+3JAMA Network+3